2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10431
    Stigmane B 98%
    Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects.
    Stigmane B
  • HY-N10486
    BChE-IN-10 2185837-61-8 98%
    BChE-IN-10 (compound 6) is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC50 value of 6.4 μM. BChE-IN-10 can be isolated from Bletilla striata. BChE-IN-10 can be used for the research of Alzheimer's disease (AD).
    BChE-IN-10
  • HY-N10487
    Bleformin A 1980064-35-4 98%
    Bleformin A is a potent BChE inhibitor with an IC50 value of 5.2 μM. Bleformin A is a nature product that could be isolated from Bletilla striata. Bleformin A can be used for research of Alzheimer's disease (AD).
    Bleformin A
  • HY-N10488
    BChE-IN-11 133740-30-4 98%
    BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
    BChE-IN-11
  • HY-N10489
    BChE-IN-12 136966-86-4 98%
    BChE-IN-12 (compound 12) is a potent butyrylcholinesterase (BChE) non-competitive inhibitor with an IC50 value of 2.3 μM. BChE-IN-12 can be isolated from Bletilla striata. BChE-IN-12 can be used for the research of Alzheimer's disease (AD).
    BChE-IN-12
  • HY-N10490
    Blestrin D 145701-19-5 98%
    Blestrin D is a potent butyrylcholinesterase (BChE) mixed-type inhibitor with an IC50 value of 8.1 μM. Blestrin D can be isolated from Bletilla striata. Blestrin D can be used for the research of Alzheimer's disease (AD).
    Blestrin D
  • HY-N10497
    Dihydro-β-erythroidine 23255-54-1 98%
    Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced.
    Dihydro-β-erythroidine
  • HY-N10512
    Gangliotetraose 75645-24-8 98%
    Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain.
    Gangliotetraose
  • HY-N10701
    AChE/BChE-IN-11 80443-12-5 98%
    AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC50 values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research.
    AChE/BChE-IN-11
  • HY-N10781
    Isograndifoliol 1445475-53-5 98%
    Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases.
    Isograndifoliol
  • HY-N10782
    Balanophonin 80286-36-8 98%
    Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.
    Balanophonin
  • HY-N10887
    Withasomniferolide B 2365386-75-8 98%
    Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera.
    Withasomniferolide B
  • HY-N10939
    Gluco-obtusin 960135-79-9 98%
    Gluco-obtusin is an anthraquinone. Gluco-obtusin can be isolated from the seeds of Cassia obtusifolia.
    Gluco-obtusin
  • HY-N10967
    Isoatriplicolide tiglate 133559-39-4 98%
    Isoatriplicolide tiglate is a bioactive sesquiterpene lactone. Isoatriplicolide tiglate can be isolated from Paulownia coreana. Isoatriplicolide tiglate has neuroprotective effect.
    Isoatriplicolide tiglate
  • HY-N1100R
    Vasicinone (Standard) 486-64-6
    Vasicinone (Standard) is the analytical standard of Vasicinone. This product is intended for research and analytical applications. Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders.
    Vasicinone (Standard)
  • HY-N11061
    Withaphysalin D 91599-21-2 98%
    Withaphysalin D is a selective antagonist against the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B. Withaphysalin D can be isolated from water lilies and has neuroprotective properties. Withaphysalin D is able to cross the blood-brain barrier.
    Withaphysalin D
  • HY-N11172
    Schibitubin I 1609628-72-9 98%
    Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata.
    Schibitubin I
  • HY-N11286
    Tridocosahexaenoylglycerol 124596-98-1 98%
    Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases.
    Tridocosahexaenoylglycerol
  • HY-N11443
    Acetyllycoposerramine M 1402242-53-8 98%
    Acetyllycoposerramine M is a lycopodine-type alkaloid, which can be isolated from Lycopodium japonicum. But Acetyllycoposerramine M has no inhibitory effect on acetylcholinesterase.
    Acetyllycoposerramine M
  • HY-N11640
    Methyl Ganoderic acid B 81907-65-5 98%
    Methyl Ganoderic acid B is a triterpenoid, that can be isolated from Ganoderma lucidum. Methyl Ganoderic acid B has nerve growth factor-like neuronal survival-promoting effects.
    Methyl Ganoderic acid B
Cat. No. Product Name / Synonyms Application Reactivity